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More Sensitive, High Resolution and Faster – all at the same time?!?!

Iyke’s latest paper outlines EXACT-PSYCHE – Broadband homodecoupled 1H NMR spectra, collected up to 4-times faster than the standard experiment (with some clever IST-based processing from our Krzysztof and Alexandra (University of Warsaw) and Carlos (MestreLab Research). It’s a nice … Continue reading

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Literally curing cancer….

[A wandering thought from Craig….] I always wanted to be either a rocket scientist or cure cancer….. I made a good start, when the compound I worked on during my PhD (tetranitromethane) was indeed studied as a rocket fuel additive. … Continue reading

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What exactly is a perverted tendril?

Well, if you want to know I suggest you have a look at Jonathan Clayden’s latest report in Chemical Science. It’s a beautiful exposition of chemical synthesis, analysis and computation, combined to understand the structure and dynamics of ‘faults’ in … Continue reading

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First Papers for Claire, Alex and Alice!

Claire’s first paper from her PhD research, shared with Alex and Alice from their undergraduate projects, has come out in The Analyst (http://pubs.rsc.org/en/content/articlepdf/2017/an/c6an02298g) today. A beautiful exposition of what NMR methods allow us to most efficiently, most easily and most accurately … Continue reading

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Dr Ndukwe

Iyke passed his PhD viva on December 9th – having been grilled by Dr James Keeler and Professor Matt Crump. Congratulations Dr Ndukwe!

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Fast, Safe and EXACT – ASAPHSQC acquisition.

Iyke’s  EXACT method for burst-sampled acquisition (see 14th July post below) in the direct dimension of NMR experiments has been extended in his latest paper to the reduction in duty-cycle of the demanding ASAP-HSQC experiment. The resulting EXACT ASAP-HSQC experiment can be acquired in … Continue reading

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Craig, MestreLab Research and qNOE

Craig has just presented a webinar for MestreLab Research SL on quantitative NOE analysis for small molecules. It gives an outline of how we (currently!) analyse NOE data to extract accurate interproton distances, looks at some of the problems which … Continue reading

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How EXACTly can we measure our data?

Iyke’s latest publication has just come out online – “EXtended ACquisition Time (EXACT) NMR—A Case for ′Burst′ Non-Uniform Sampling” describes a novel approach to Non-uniform sampling in the direct dimension of NMR spectra which allows us to extend the acquisition times … Continue reading

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It’s getting hot in here!

Catharine and Jess’s paper on NOE measurements being used to elucidate tiny changes in conformer populations with temperature has been accepted for publication in Chem Comm. They quantified changes of ~98:2 to ~96:4 in conformer populations with increasing temperature for … Continue reading

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Iyke’s First Paper

Iyke has published his work on increasing sensitivity and resolution in EXSIDE measurements: Pure-shift IMPRESS EXSIDE – Easy measurement of 1 H- 13C scalar coupling constants with increased sensitivity and resolution Sensitivity is increased up to 1000% in some of … Continue reading

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