What exactly is a perverted tendril?

Well, if you want to know I suggest you have a look at Jonathan Clayden’s latest report in Chemical Science. It’s a beautiful exposition of chemical synthesis, analysis and computation, combined to understand the structure and dynamics of ‘faults’ in helixes formed by conformationally constrained polypeptides.

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First Papers for Claire, Alex and Alice!

Claire’s first paper from her PhD research, shared with Alex and Alice from their undergraduate projects, has come out in The Analyst (http://pubs.rsc.org/en/content/articlepdf/2017/an/c6an02298g) today. A beautiful exposition of what NMR methods allow us to most efficiently, most easily and most accurately measure the 2- and 3-bond 13C-1H coupling constants (unfortunately no method does all three optimally, but read it to find out what might work best for you!).

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Dr Ndukwe

Iyke passed his PhD viva on December 9th – having been grilled by Dr James Keeler and Professor Matt Crump. Congratulations Dr Ndukwe!

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Fast, Safe and EXACT – ASAPHSQC acquisition.

Iyke’s  EXACT method for burst-sampled acquisition (see 14th July post below) in the direct dimension of NMR experiments has been extended in his latest paper to the reduction in duty-cycle of the demanding ASAP-HSQC experiment. The resulting EXACT ASAP-HSQC experiment can be acquired in as little as 6 seconds, allowing him to monitor reaction kinetics which occur on the second-minute timescale.

Graphical abstract: Rapid and safe ASAP acquisition with EXACT NMR

Whatever will he think of next? Well, who knows… but presumably it will happen ASAP. And be rather EXACT!

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Craig, MestreLab Research and qNOE

Craig has just presented a webinar for MestreLab Research SL on quantitative NOE analysis for small molecules. It gives an outline of how we (currently!) analyse NOE data to extract accurate interproton distances, looks at some of the problems which can arise, how to circumvent (some of) them, and finally presents a couple of our recent case studies.

 

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How EXACTly can we measure our data?

Iyke’s latest publication has just come out online – “EXtended ACquisition Time (EXACT) NMR—A Case for ′Burst′ Non-Uniform Sampling” describes a novel approach to Non-uniform sampling in the direct dimension of NMR spectra which allows us to extend the acquisition times of certain NMR experiments which are currently limited in this sense. Applications to HSQC (>1 second acquisition, with 13C decoupling) and Pureshift EXSIDE (described recently by Iyke in his last paper!) show the potential benefits of this. Watch out for more in the near future……

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It’s getting hot in here!

Catharine and Jess’s paper on NOE measurements being used to elucidate tiny changes in conformer populations with temperature has been accepted for publication in Chem Comm. They quantified changes of ~98:2 to ~96:4 in conformer populations with increasing temperature for a couple of small molecules with accuracies greater than could be achieved with some fairly high-level calculations. It’s taken a while to get all the details right, but a beautiful paper is the final product. Well done folks!

 

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Iyke’s First Paper

Iyke has published his work on increasing sensitivity and resolution in EXSIDE measurements:

Pure-shift IMPRESS EXSIDE – Easy measurement of 1 H- 13C scalar coupling constants with increased sensitivity and resolution

Sensitivity is increased up to 1000% in some of his results – not bad for a little pulse programming and macro-writing…..

Quite rightly, Iyke is celebrating with a holiday back home to meet his new baby.

 

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Siying joins the group!

Siying
Siying Zhong, fresh out of her Chemical Synthesis Centre for Doctoral Training bootcamp has joined the group. She is co-supervised for her PhD by Professor Varinder Aggarwal, and splits her time between synthesis with his group and NMR/computation with ours.

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Comings and Goings

So it’s been a hectic couple of months, and this is a little late, but the group has stepped forward another year, and there have been a few changes recently:

Godi passed her PhD viva back in September and left us in October to return to Botswana – she will be truly missed, but her return to the NMR lab and family/friends in Botswana has certainly put a smile on her face!

Claire Dickson  has joined us for her PhD, sponsored by C4X Discovery, and is rapidly learning the ins-and-outs of nJCH measurements, a bit of synthesis and now Xray crystallography…. she’s in for a fun few years!

Tom Leman hasn’t quite got around to leaving yet – in fact he’s signed up for another year of NMR, undertaking an MSci(Res) looking at new ‘Karplus equations’ for 2-bond CH couplings… he’s already turned up a couple of interesting empirical facts, so we’re looking forward to seeing where this all goes.

Lydia, Alice, Toby and Ben have also joined the ranks to undertake their final year research projects being overseen by Jess, Tom, Claire and Iyke respectively…. somebody save them…….

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