We have a PhD studentship available, in collaboration with C4X Discovery investigating “Spectrum to Structure – Improving NMR methods to solve 3D molecular structure in solution”.
Background: Ligand-based drug design relies very heavily on understanding and mimicking the 3D structure and dynamics of molecules in solution. Even with modern NMR methods however, working out conformation (and stereochemistry if it is unknown) is often a challenge to both chemists and spectroscopists alike – and when you have a flexible molecule with multiple conformations, the challenge increases by an order of magnitude.
Project Outline: This project will develop new NMR-based methods to elucidate 3D molecular structure – primarily targeting new experimental approaches and treatments of H-C couplings and NOEs, allowing improvements to the advanced computational technologies developed by C4X Discovery to target drug-like molecules of interest. During the PhD, you will work with a mixture of NMR method development, data analysis, computational chemistry, and it will include a multi-month placement at C4X Discovery to apply your results in their drug discovery program.
Informal enquiries can be directed to Craig.Butts@bris.ac.uk.
You can apply from here
We have had five new members join the group in October. Jess Bame, our US-attache begins her PhD examining NOE-Distance relationships and their applications to molecular conformational and structure determination in solution. Steph Bull, Nicky Kilburn, Thomas Floyd and Thomas Leman all start their final year research projects examining NOE/J-based structure analysis, constant-time HMBC, and applications of 60MHz NMR to undergraduate education. We’re looking forward to a great year ahead!
Catharine screamed (not literally) through her PhD viva with Prof. Gareth Morris and Dr Matt Crump – with minor corrections to come before Doctor-hood becomes hers. Well done Catharine, now just a short post-doc, house-moving and a wedding to get through in the next couple of months……
Ikenna Edward Ndukwe has joined us from his native Nigeria to undertake his PhD research making Improvements (we hope!) to Small Molecule NMR Experiments. Welcome to the mad-house Iyke – we hope you enjoy it!
Some of our ongoing work in Automated 3D Structure Elucidation – directly from NMR data – has been discussed in an article in the RSCs “Chemistry World”. We’ve included a video demonstration of our the prototype software in action – which you can now view here:
One can never take citations as the sole arbiter of quality or recognition in academic science, but on the other hand one should never miss the chance to blow a trumpet! Catharine’s recent JOC paper is currently the 5th most cited 2012 paper in Journal of Organic Chemistry (see the screenshot image from Web of Knowledge)….. A similar glance at her recent publications reveal that her Beilstein Journal of Organic Chemistry paper last year holds a similar top-10 position amongst 2011 BJOC papers….. Not bad at all…….
Congratulations to Paul Brown, who passed his PhD viva with flying colours (or at least, they didn’t throw him out!) and is now ready to skip across the ditch to his post-doctoral position in Boston in the new year. He’s had a great PhD – supervised by Julian Eastoe and myself (I’ll take the credit, while Julian did the hard work), undertaken some fantastic research, developed his own and his colleagues skills enormously and published profusely (with a couple more on their way…. watch this space).
Congrat’s mate – sorry to see you go!
Paul has just had another paper accepted – entitled “Microemulsions as tunable nanomagnets” (DOI: 10.1039/C2SM26827B) – in Soft Matter this month. Congrats Paul – that is 5 papers in 2012!
Hot on the heels of magneto-emulsions, Paul has now had a manuscript accepted into Advanced Materials (“Magnetizing DNA and Proteins Using Responsive Surfactants”) looking at manipulating biomaterials with his magical magnetic IL surfactants. Well done Paul!
Catharine will be presenting her work on NOE-distance measurements at SMASH2012 (http://www.smashnmr.org/) where she is speaking in a session entitled “Beyond Conventional NMR Experiments for Determination of Configuration” with a few unknowns (Griesinger, Reggelin, Giraudeau)……. Not a bad job if you can get it.